Muscle Protein Synthesis, Early Onset Parkinsons, Creatine and Kidney Function | THRR144

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Muscular exercise can cause highly pathological liver function tests in healthy men

Muscle Protein Synthesis

Laura says:

Hi Robby and Nicki

I'm a 45 year old female and have been listening to lots of things protein related recently. It seems like "experts" from many backgrounds seem to agree on the importance of protein, especially as one ages. Meeting a leucine threshold in a meal seems to be a common consensus as well. I love meat and hit that target with no issue 3x per day. However, what I've never heard any of these protein experts talk about is a "stimulus" threshold for MPS. They all talk about weight lifting being a MPS signal but I've never heard of a minimum required dose. I was wondering if in your reading/learning you've heard anyone talk about the minimum "strength workout" needed to initiate MPS. Or is it relative? Like my doing 2 sets of max rep pull ups gets a little MPS going but an hour long leg workout with leg press, deadlifts, RDLs, split squats triggers more? Any insights here would be appreciated! Thanks :)

Early onset Parkinsons and a different approach

Amy says:

First I want to say I love you guys. I'm always trying to obtain more knowledge in the health and wellness field as a Firefighter/Paramedic and Fitness Coach as a part time. Your show is easy and fast knowledge. Plus I love LMNT. The chocolate medley is my favorite.

Now my question. Recently my husband had a hand tremor experience. Early in the morning in bed where it woke me up. He didn't mention it for a couple days but when he did I realized it concerned him as well. He is your typical male that doesn't want to seek medical advice and had to be dragged to the doctor years ago when I suspected a DVT. We found out he had the largest his physician had seen from his ankle to his hip and 3 PEs. ( Pre covid, no he is not vaccinated) we found out it was a genetic disorder. Since the tremor, in my own research I feel like he has a lot of early signs for Parkinsons which I may be me jumping ( but so was the DVT at the time) but this is so concerning. We take a more functional approach to our health and I was wondering your thoughts on that for Parkinsons. I have a previous client where we found weight training really helped his tremors but also any emotional response could make it worse.

My husband is healthy, 45, weight trains multiple times a week and does a lot of zone 2 training. Only medical history is the clotting disorder for which he takes Eliquis. Sorry for the long question. Thanks in advance.

Kidney function and protein with age

Dawn says:

Hello Robb and Nicki,

A friend of mine in her late 40’s is following a mostly paleo diet and has been increasing animal proteins and working on resistance training to increase muscle mass the last few years to help with healthy aging, glucose control, maintaining function etc. She has recently started including creatine supplementation to help with brain and muscle function as per all sorts of recommendations from various ppl in the healthy aging and menopause space. She has relatively low body fat (visible abs and shoulder muscles) and has only a couple drinks a week. She uses LMNT daily.

She just received blood work results showing higher than normal creatinine and ALT levels and is wondering whether to stop creatine supplements. Also,

she will be booking in to see a renal doc to discuss further but is worried because all conventional advise for kidney disease

Appears to be: go on a low protein diet, eat vegetable oils, “healthy” whole grains etc….which completely flies in the face of her experience of better health and body comp for years on a more ancestral style diet with increasing protein over time.

She has experienced several UTIs in the last year which could be due to estrogen dropping post hysterectomy (therefore she is menopausal) and recently had covid…so there is a history now of urinary infection AND it seems that some people experience renal issues post virus.

Any suggestions on protein and creatine? Resources we can research so she can make informed choices? It’s scary that the conventional dietary changes are totally opposite what someone needs to do to retain good muscle mass as one ages, and they seem to promote higher glucose levels over time which we know will lead to diabetes.

Thanks so much for any light you can shed. It can be difficult when you are trying to buck the normal trend of decline with middle age by doing seemingly the opposite of what the doctors tell us to do.

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