Scientists talk about what they do and why they do what they do. Their motivations, their trajectory, their setbacks, their achievements. They offer their personal take on science, mentoring and the many aspects that have shaped their work and their lives. Hosted by journalist Vivien Marx. Her work has appeared in Nature journals, Science, The Economist, The NY Times, The Wall Street Journal Europe and New Scientist among others. (Art: Justin Jackson)
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Sneak-peek of the ISSCR annual meeting 2024
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Stem cells are intriguing cells with a lot of flexibility in their biographies. And these cells are the focus of the annual meeting of the International Society for Stem Cell Research, ISSCR. It's happening soon: in July. Here is a sneak-peek of the meeting with the ISSCR leadership: Dr. Amander Clark from the University of California at Los Angele…
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A chat with NSF director Dr Sethuraman Panchanathan
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This podcast is with Dr Sethuraman Panchanathan who directs the US National Science Foundation. He talks about his nickname, about AI and data science, about training AI models, about transparency, about the language of collaboration, competitiveness, about talent. He says: "I think what we need as a nation is not only to unleash every ounce of tal…
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Can you be a scientist and parent? Of course. But it's not always easy. Dr. Ying Diao is at the University of Illinois Urbana Champaign in the chemical and biomolecular engineering department. She has a stack of awards, a lab and two children. She talks about her research, for instance a project focused on wearable electronics for plants with which…
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This episode is about dirt or, phrased more scientifically, soil. It’s about soil health, soil biodiversity and ecology. It’s a conversation with Dr. Ciska Veen, soil and ecosystems researcher at the Netherlands Institute of Ecology and Dr. Wim van der Putten, who heads terrestrial ecology at the Netherlands Institute of Ecology. (Art: J. Jackson; …
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Persistence and success in science
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Jean King, who is the dean of arts and sciences at WPI-Worcester Polytechnic Institute in Worcester, Massachusetts, talks about what Nobel Laureate Katalin Karikó means to her and about persistence and success in science. (Art: J. Jackson; Music: Towers by sero, licensed from artlist.io)द्वारा Vivien Marx
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How to get big projects to soar: Anna Barker, Ellison Institute and former principal deputy director of the US National Cancer Institute
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What good does it do to start a big research project? How do you get it to soar? Dr. Anna Barker has some answers about that from the past, the present and the future. She is chief strategy officer at the Ellison Institute, a think tank and research institute. Before that, she was the principal deputy director of the US National Cancer Institute an…
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The Society for Neuroscience annual meeting, a big conference in neuroscience, is about to start. This year, it's in Washington. And here is a sneak peek of the meeting for you. Along with editors at Springer Nature, I got the chance to ask a bit about the meeting before it starts shortly. It was a mash up of a press conference of sorts and a wider…
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When housing insecurity gets in the way
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Science and academia need diversity. Easier said than done because, for example, many students face housing insecurity, which keeps them from a focus on their studies. But that's something students are trying to change. I spoke with current and former students at UC Santa Cruz about this. In this episode you will hear from Abbi Cundall, Natalie Cli…
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Labs and a lab's team members often speak many languages. Science is international. But in a lab environment languages can set people apart. I wrote a story about lab languages for Nature Methods here: https://rdcu.be/doPnv There's a blog post here: https://cellmolbiocommunity.springernature.com/posts/podcast-lab-languages . And here is more from t…
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Dr. Liz Bradley, who is on the computer science faculty at the University of Colorado Boulder, is an athlete-scientist. She is a mathematician and a former Olympic rower. In this podcast you will hear about her, about sweeping and sculling, about rugby, why it's good to have a notebook, about data analysis and some pitfalls that can happen in data …
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Science and the arts have much to say to one another. This episode is a conversation between scientists and artists, between scientists who foster the arts through fellowships and residencies and artists active in science and people who live in both worlds: science and the arts. All this makes for interesting and sometimes challenging groups of ide…
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Trees: A conversation with David Neale, University of California, Davis
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A conversation with David Neale, professor emeritus of the University of California Davis and director of the Whitebark Pine Ecosystem Foundation. As a forester and scientist, he works on trees, also the genomics of trees to understand more about their longevity and adaptability to events such as climate change. And he wants to empower the next gen…
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University of California San Diego researcher Dr. Gene Yeo is an athlete-scientist. He has completed two Iron Man competitions, a number of half Iron Man competitions and both full and half marathons. He says: "On these long long runs and long bike rides, you know, you get the time to sort of zone out a little bit, right. And it helps you focus on,…
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Cells push things around and get pushed around, it's all in a day's work. Tracking this, such as by tracking actin and the cytoskeleton, takes microscopy and labels. Lifeact, for example, is a popular, widely used label. This conversation is with the Lifeact developers Dr. Michael Sixt from Institute of Science and Technology Austria and Dr. Roland…
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Long-read sequencing: Steven Salzberg, Johns Hopkins University
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Dr. Steven Salzberg is a Johns Hopkins University researcher and director of the Center for Computational Biology at Hopkins. I spoke with him about genomics, about long-read sequencing, about human biology and human diversity, about funding, technology choice, about complete and incomplete genomes, about jobs in bioinformatics. He described his te…
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Long-read sequencing: Gordon Sanghera, CEO of Oxford Nanopore Technologies.
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When scientists want to know about genes, chances are they use instruments called sequencers. Some of them can generate long-reads, which helps with analyzing genomes. The method of the year according to Nature Methods is: long read-sequencing. For a story I chatted with scientists at companies and in academia about long-read sequencing and did som…
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Long-read sequencing: Jonas Korlach, CSO of Pacific Biosciences
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When scientists want to know about genes, chances are they use instruments called sequencers. There are quite a few companies that make sequencers. These instruments can give a read-out for example of a stretch of DNA or many stretches of DNA, even entire genomes and many genomes. The challenge has been that the instruments deliver--short reads—sho…
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Dr Uri Manor is a researcher at the Salk Institute who studies the dynamics of cells and Aly Putnam is a PhD student at University of Massachusetts in Amherst. They work in different fields and they are at different career stages. What they have in common is that they both have faced and continue to face adversity. They face an adversity of, the mo…
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Recently, we had the chance to get a sneak-peek of the meeting with the Society for Neuroscience's current leadership and to play a nerdy game with them. They are: Dr. Gina Turrigiano, Brandeis University researcher and current President of the Society for Neuroscience, Dr. Robbie Greene of the University of Texas Southwestern Medical Center, curre…
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Creative grit: the Global South takes on COVID-19, Episode 3
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This is a podcast series with some of the people I spoke with for a story about the creative grit scientists in The Global South apply in the fight against COVID-19. They collaborate, they network, they get creative to get what they need: supplies and strength for their research. In the haste to clinical trials for the COVID-19 vaccines some people…
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A conversation with sailor-scientist Romain Troublé Tara Ocean Foundation. He is executive director of the foundation devoted to the ocean and ocean research. And there's a connection to the French fashion house agnès b. You have perhaps heard of the gut microbiome, the many microbes in our gut that play a large role in maintaining our health. The …
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Models are important tools: they resemble, they mimic, they imitate something to a greater or lesser extent. How similar models are to the 'real thing' is usually a challenging issue. And it's a big issue with stem-cell derived models of the human embryo. These embryo models, models of the embryo's 8-cell stage, of the blastocyst or of the gastrula…
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Creative grit: the Global South takes on COVID-19, Episode 2
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I asked Dr. Leo Poon, who co-directs the Hong Kong University Pasteur Research Pole, if he has a fleet of private jets. He does not. But he wishes he did. He and his team have helped colleagues all over the world on COVID-19. He and his team developed a diagnostic assay quite soon after the genome sequence of SARS-CoV-2, the virus that causes COVID…
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How is the Russian invasion of Ukraine affecting scientists? Here is another episode on this with a conversation with Dr. Svitlana Dekina, a researcher at the A.V. Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine in Odessa, Ukraine. She has recently left Ukraine and is now at the European Molecular Biology Laborato…
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The Russian invasion of Ukraine is affecting scientists in many different ways. Here is a conversation with Dmytro Gospodaryov, a researcher in the department of biochemistry and biotechnology at Vasyl Stefanyk Precarpathian National University in Ivano-Frankivsk, West Ukraine. I spoke to him shortly after the Russian invasion in Ukraine began. And…
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Creative grit: the Global South takes on COVID-19, Episode 1
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Virologist Dr Marycelin Baba from the University of Maiduguri in northeastern Nigeria is passionate about her work on viruses, She runs a World Health Organization (WHO)-accredited and WHO-sponsored lab where the team has worked, for example, on polio. When COVID-19 emerged, she and her team were prepared and she was called upon to help build capac…
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The CRISPR Children, Episode 4
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Around three years ago, three children were born with genomes edited before their birth. They are supposedly doing ok, sources tell me. But it's hard to know for sure. Germline-genome editing is not permissible in most countries, but it might one day be performed to avoid heritable diseases that are incurable. But the technology needs to be much mo…
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Predicting protein structure, episode 4
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This episode is about AlphaFold and the impact it is having on junior scientists. I spoke with a group of them from different labs at the Max Planck Institute of Biochemistry. I spoke with Dr Isabell Bludau, a postdoctoral fellow and computational biologist in the lab of Dr Matthias Mann, Dr. Bastian Bräuning, a postdoctoral fellow and project grou…
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Predicting protein structure, episode 3
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Biology and AI for predicting protein structure. This is a chat with conversation with some members of the Rost lab at the Technical University of Munich. Dr. Maria Littmann, postdoctoral fellow, and PhD students Konstantin Weissennow and Michael Heinzinger and Dr Burkhard Rost, principal investigator. We talked about AlphaFold, a computational app…
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Predicting protein structure, episode 2
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Protein structure prediction is the Nature Methods Method of the Year for 2021. Here is my feature on that. https://www.nature.com/articles/s41592-021-01359-1 For the story, I chatted with Helen Berman, co-founder of the Protein Data Bank (PDB), which is home to experimentally determined structural data for over 180,000 proteins. What's next for th…
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Predicting protein structure, episode 1
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Proteins are twirly, curly, dynamic structures. Crucial for life, complicated to study. Predicting protein structure has been tough but it's now easier as AlphaFold enters the scene. That doesn't mean that AlphaFold has solved all challenges, of course. AlphaFold was developed by DeepMind Technologies, a company that was bought by Google in 2014. L…
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To go along with my investigative story The CRISPR Children in Nature Biotechnology, I am producing a rolling series of podcasts. This episode is a chat with Dr. Eben Kirksey, an anthropologist at Deakin University, which has campuses in and near Melbourne, Australia. He has written a book called The Mutant Project, Inside the Global Race to Geneti…
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The CRISPR Children is a podcast series about the children whose genomes were edited before their birth in 2018. The podcasts accompany a story I did about these children in Nature Biotechnology by the same name. You can find the story here: https://rdcu.be/cB7Nx The children were born somewhere in China. They came about due to experiments performe…
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The CRISPR Children is a series of podcasts about the children whose genomes were edited before their birth in 2018. The podcasts accompany a story I did about these children in Nature Biotechnology by the same name. You can find the story here: https://rdcu.be/cB7Nx The children were born somewhere in China and the result of experiments performed …
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Neuroscientists use models of the brain to study the brain. One of those model types: organoids. One way to get a conversation with a neuroscientist started badly is to ask them about the 'mini-brains' in the dish on their lab bench. It’s not that the blob in the dish doesn’t somehow look like a piece of living tissue that could be a piece of brain…
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This podcast is with Dr. Hongkui Zeng who directs the Allen Institute for Brain Science and Dr. Bolisjka Tasic who directs Molecular Genetics at the Allen Institute for Brain Science. It’s about how spatially resolved transcriptomics, a Nature Methods Method of the Year, can help to understand the brain. I did a story about it here: https://www.nat…
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This podcast is about two scientists, Dr. Patrik Ståhl and Dr. Fredrik Salmén, who are joint first authors of a paper that kickstarted a field. It's about finding work they did with colleagues to enable finding out where in tissue gene expressions is happening. It's called spatially resolved transcriptomics. It is a Nature Methods Method of the Yea…
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Marine echinoderms speak to developmental biologist Dr. Paola Oliveri at University College London for many reasons. Their evolution of a novel body plan is one of them. In a conversation she talks about teaching evolution, her training, her students and her love of science.द्वारा Vivien Marx
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Long-COVID Part 3: A chat with Terina Martinez
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COVID-19 has been bad. Many, likely millions of people, who have survived their COVID-battle, face a difficult array of symptoms. Breathing problems, joint pain, heart palpitations, brain fog are a few of them. This is part 3 of a three-part podcast series on long-COVID. This episode is a conversation with Dr. Terina Martinez, a field application s…
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Long-COVID Part 1: A chat with Nadia Rosenthal
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COVID-19 has been bad. Many, likely millions of people, who have survived their COVID-battle, face a difficult array of symptoms. Breathing problems, joint pain, heart palpitations, brain fog are a few of them. This is part 1 of a three-part podcast series on long-COVID. You can also find my piece in Nature Methods on long-COVID here. Dr. Nadia Ros…
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Long-COVID Part 2: A chat with Avi Nath
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Around the world, COVID-19 has been awful. Many, likely millions of people, who have survived their COVID-battle, face a difficult array of symptoms. Breathing problems, joint pain, heart palpitations, brain fog are a few of them. This is part 2 of a three-part podcast series on long-COVID. This episode focuses on brain fog, one of the difficult sy…
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She's driven by curiosity. Na Ji is a physicist and neuroscientist at University of California, Berkeley. She develops ways to study the brain and she reads voraciously. She seeks to capture the signals that neurons pass to another with imaging and in multiple brain regions. She also teaches a class for people interested in physics. She calls it 'P…
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This episode of Conversations with ..Scientists--Bye-Bye Bunny-- is about research into diseases such as COVID-19 and neurological diseases, too. It's about the antibodies in our bodies. And it's about research antibodies. And it explores the possibility of perhaps generating and producing research antibodies without the use of animals. It includes…
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Computational pipelines: to build and maintain them
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Pipelines are basically a series of steps. Algorithms are linked to one another, the output of one algorithm is the input to another. Pipelines can be simple and pretty complex. And maintenance of pipelines also ranges from simple to complex. They can run like a dream, they can get stuck, they can break. To talk about trends in this area, I sat dow…
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Part I of the annual meeting of the American Association for Cancer Research—it was all virtual—had 61,000 attendees. Part II is about to start. Here’s a sneak peek about the meeting, its hundreds of talks and thousands of posters. Virtual conferences mean less of a carbon footprint, maybe a broader reach and a chance for attendees who cannot typic…
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Part I of the annual meeting of the American Association for Cancer Research was all virtual. There were 61,000 attendees, including some job-hunters. I wonder how this year’s conference that is about to get underway will affect job-hunting. This episode is with scientists talking about their hopes and allergic points as they job-hunt. It’s based o…
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Today’s episode is with and about Hui Yang. Dr. Yang is a researcher at the Institute of Neuroscience at Shanghai Institutes for Biological Sciences, which is part of the Chinese Academy of Sciences. He has developed new base-editor variants. Base-editing is a kind of gene-editing. Overall the result led to base-editors with fewer off-targets, high…
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Proteins in a cell don't tend to practice social distancing. They have many associates but capturing all of the associates in one experiment is difficult. Dr. Carol Robinson and her team developed a way to be able to dissociate such complexes in a mass spectrometer and look at them in one experiment. It's a new kind of mass spectrometer and one she…
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