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A New(-ish) Antacid Medication
Manage episode 437593486 series 3476336
Jody Marks, MSN, AGACNP-BC, FNP-BC, Jody Marks, and MSN द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री Jody Marks, MSN, AGACNP-BC, FNP-BC, Jody Marks, and MSN या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal।
The new PCAB Voquenza (vonoprazan) is being marketed as a superior alternative to PPI therapy for acid-related conditions (GERD with or without erosive esophagitis, H. pylori eradication). Are these two mechanisms of action really that different? Jody investigates.
References:
1) Prescriber information: https://www.phathompharma.com/wp-content/uploads/VOQUEZNA-tablets-Prescriber-Information.pdf
2) György Miklós Buzás, Dual acid-pump blocking as novel therapeutic approach to treatment of acid-related diseases, Medical Hypotheses, Volume 187, 2024, 111338, ISSN 0306-9877, https://doi.org/10.1016/j.mehy.2024.111338.
3) Katzka DA, Kahrilas PJ. Potassium-Competitive Acid Blocker Suppression of Gastric Acid in Erosive Esophagitis: Is Stronger and Longer Better? Gastroenterology. 2023 Jan;164(1):14-15. doi: 10.1053/j.gastro.2022.10.022. Epub 2022 Oct 28. PMID: 36341738.
4) Shin JM, Sachs G. Pharmacology of proton pump inhibitors. Curr Gastroenterol Rep. 2008 Dec;10(6):528-34. doi: 10.1007/s11894-008-0098-4. PMID: 19006606; PMCID: PMC2855237.
5) Simadibrata DM, Syam AF, Lee YY. A comparison of efficacy and safety of potassium-competitive acid blocker and proton pump inhibitor in gastric acid-related diseases: A systematic review and meta-analysis. J Gastroenterol Hepatol. 2022 Dec;37(12):2217-2228. doi: 10.1111/jgh.16017. Epub 2022 Oct 26. PMID: 36181401; PMCID: PMC10092067.
6) Oshima T, Miwa H. Potent Potassium-competitive Acid Blockers: A New Era for the Treatment of Acid-related Diseases. J Neurogastroenterol Motil. 2018 Jul 30;24(3):334-344. doi: 10.5056/jnm18029. PMID: 29739175; PMCID: PMC6034668
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