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Lipoprotein a
Manage episode 362445621 series 3473125
Dr. Hussien Heshmat द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री Dr. Hussien Heshmat या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal।
- Lipoprotein a is a molecule produced by the liver, similar to LDL in structure, with a peculiar protein that gives it wide variability.
- Elevated lipoprotein little (a) is causal of atherosclerotic disease, recurrent strokes, and aortic calcification. Smaller forms of LPa are riskier. LPa is not a risk factor for venous thromboembolism
- The levels are determined genetically with minimal impact from lifestyle.
- Normal values are 125 nmol/L)
- Levels should not be converted from mg to mmol or vice versa
- Levels should be measured once in the lifetime
- The excess risk of LPa elevation can be mitigated by additional LDL lowering and tighter CV risk factor control.
- PCSK9i(s) reduces the levels by 25%, but they are not approved for this indication.
- Aspirin may be beneficial as primary prevention in individuals with genetic variants that elevate LPa.
- Specific therapies are being developed to lower LPA by >70% and may be released three years from now.
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