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Thomas Sudhof: Molecular Codes for Synapse Formation and Specificity
Manage episode 407153275 series 3558288
Mark Mattson द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री Mark Mattson या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal।
In this episode I talk with Stanford Professor and Nobel laureate Thomas Sudhof about his work that has advanced an understanding of the molecular machinery for neurotransmitter release, a remarkable process that is compex, occurs rapidly (milliseconds) and is highly localized (1 micrometer or less). We then talk about the even more difficult problem of the molecular mechanisms that control the formation, maintenance and plasticity of synapses. The current model of the molecular code for synapse specificity and adaptability involves a uniform array of presynaptic proteins and a highly variable array of postsynaptic proteins.
LINKS
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3866025/pdf/nihms-531222.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226307/pdf/nihms-1509679.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5689449/pdf/nihms914499.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694349/pdf/nihms917636.pdf
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