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Beyond the Abstract द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री Beyond the Abstract या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal।
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Beyond the Abstract द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री Beyond the Abstract या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal।
Hey science nerds! Welcome to Beyond the Abstract, a science podcast dedicated to discussion of the coolest cutting edge, basic science research papers in a way that just about anyone can understand. We're your hosts, Derek, Dan, and Ellen, three MD/PhD students coming from the University of Pennsylvania and Harvard Medical School who are passionate about science communication and bridging the gap between science and medicine. In each episode, we’ll dive into a paper and talk about the experiments these scientists did, what it means for the future of research, and even potential impacts on human health and medicine. We've invited experts in these fields to help us understand and dissect these complicated but impactful papers. We can't wait to share all this cool science with you. Disclaimer: This podcast is for informational purposes only and NOT intended as medical advice. The views and opinions expressed are those of the hosts and guests and do not reflect the University of Pennsylvania. Business contact: beyondabstractpod@gmail.com
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42 एपिसोडस
सभी (नहीं) चलाए गए चिह्नित करें ...
Manage series 3236172
Beyond the Abstract द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री Beyond the Abstract या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal।
Hey science nerds! Welcome to Beyond the Abstract, a science podcast dedicated to discussion of the coolest cutting edge, basic science research papers in a way that just about anyone can understand. We're your hosts, Derek, Dan, and Ellen, three MD/PhD students coming from the University of Pennsylvania and Harvard Medical School who are passionate about science communication and bridging the gap between science and medicine. In each episode, we’ll dive into a paper and talk about the experiments these scientists did, what it means for the future of research, and even potential impacts on human health and medicine. We've invited experts in these fields to help us understand and dissect these complicated but impactful papers. We can't wait to share all this cool science with you. Disclaimer: This podcast is for informational purposes only and NOT intended as medical advice. The views and opinions expressed are those of the hosts and guests and do not reflect the University of Pennsylvania. Business contact: beyondabstractpod@gmail.com
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42 एपिसोडस
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1 Plaque Hacks: When it Comes to Statins, Consistency is Key 16:29
16:29
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Cardiovascular disease is the leading cause of global mortality. Among the many risk factors for cardiovascular disease, it's long been known that high cholesterol increases the risk for heart attacks and stroke. In today's episode of Beyond the Abstract, Derek and Dan discuss two new papers that challenge commonly held beliefs about the way in which cholesterol increases the risk for cardiovascular disease. They finish by talking about a new type of genetic medicine to lower cholesterol and reduce the risk for cardiovascular disease. Papers discussed Alternating high-fat diet enhances atherosclerosis by neutrophil reprogramming, Lavillegrand et al 2024 Nature https://www.nature.com/articles/s41586-024-07693-6 Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis, Takaoka et al 2024 Nature https://www.nature.com/articles/s41586-024-07993-x Zodasiran, an RNAi Therapeutic Targeting ANGPTL3, for Mixed Hyperlipidemia, Rosenson et al 2024 NEJM http://nejm.org/doi/full/10.1056/NEJMoa2404147 Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia, Ballantyne et al 2024 NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa2404143…
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1 Chasing The Fountain of Youth: The Science of Anti-Aging 27:23
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Humans have long sought the fountain of youth, and recently scientists have explored the biological basis of aging and potential strategies to reverse the process. Along with groundbreaking discoveries that have enabled extending the lifespan of model organisms, the anti-aging movement has spurred an entire industry focused on stopping the biological clock. In today's episode of Beyond the Abstract, Derek and Dan discuss recent studies about the aging process and debate the promises and pitfalls of this fast-moving field. This episode is sponsored by Proteintech Group, a company that creates reagents for the biomedical sciences so scientists can conduct groundbreaking science. Visit them at www.ptglab.com to find out more. The information presented here is not medical advice. Consult your physician for any questions regarding your personal health. Articles Discussed Abad et al. Reprogramming in vivo produces teratomas and iPS cells with totipotency features. Nature, 2013. Ross et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature, 2024. Ocampo et al. In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. Cell, 2016. Wang et al. In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche. Nature Communications, 2021. Browder et al. In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice. Nature Aging, 2022. Weindruch et al. The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. Journal of Nutrition, 1986. Lu et al. Reprogramming to recover youthful epigenetic information and restore vision. Nature, 2020. Yucel and Gladyshev. The long and winding road of reprogramming-induced rejuvenation. Nature Communications, 2024. Lopez-Otin et al. The Hallmarks of Aging. Cell, 2013. Choudhury et al. Proline restores mitochondrial function and reverses aging hallmarks in senescent cells. Cell Reports, 2024. Zeng et al. Restoration of CPEB4 prevents muscle stem cell senescence during aging. Developmental Cell, 2023.…
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1 More Than Meets the Eye: A New Portal Into Treating Brain Disorders 13:15
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Disorders of the brain are among the most challenging to treat in all of medicine. Among the challenges is access: the brain is locked away in the skull, preventing medicines from reaching their destination. To deal with this difficulty, researchers are turning to an unexpected access point to the brain: the eye. In today's episode of Beyond the Abstract, Derek and Dan discuss new papers that demonstrate neural and immune links between the eye and the brain that could soon help doctors treat diseases ranging from Alzheimer's to cancer. Articles discussed Murdock et al., Multisensory gamma stimulation promotes glymphatic clearance of amyloid. Nature. 2024 ( https://www.nature.com/articles/s41586-024-07132-6 ) Yin et al., Compartmentalized ocular lymphatic system mediates eye-brain immunity. Nature. 2024 ( https://www.nature.com/articles/s41586-024-07130-8 ) The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 Going Nuts About New Treatments for Food Allergies 14:43
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Food allergies are a major problem – common, potentially deadly, and without effective medicines to prevent them from occurring. But earlier this year, researchers and doctors published a clinical trial reporting an effective new treatment for preventing allergic food reactions. In today’s episode of Beyond the Abstract, Derek and Dan dive into the science behind the new treatment and what it might mean for the future of combating a deadly disease. Article discussed Wood et al., Omalizumab for the Treatment of Multiple Food Allergies. New England Journal of Medicine. 2024 ( https://www.nejm.org/doi/full/10.1056/NEJMoa2312382 ) The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 Xenotransplantation: How Pig Kidneys are Saving Human Lives 13:26
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Thousands of patients in the US die every year waiting for an organ transplant, often because there are not enough human organ donors. Xenotransplantation — transplantation from another species to humans — could solve this problem, but has remained the realm of science fiction given many technical obstacles. Now, with advances in gene editing, this pipe dream is becoming reality. In today's episode of Beyond the Abstract, Dan and Derek explore xenotransplantation, tell the stories of the few humans who have received pig organs, and explain why this may herald a new era in transplant medicine. Articles discussed Griffith et al. Genetically modified porcine-to-human cardiac xenotransplantation. New England Journal of Medicine. 2022. ( https://www.nejm.org/doi/full/10.1056/NEJMoa2201422 ) Anand et al. Design and testing of a humanized porcine donor for xenotransplantation. Nature. 2023. ( https://www.nature.com/articles/s41586-023-06594-4 ) The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 From Stigma to Science: A Scientist's Journey to Treat Hyperemesis Gravidarum 19:49
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While almost all women experience nausea and vomiting during pregnancy, few are debilitated by severe symptoms: a condition known as hyperemesis gravidarum (HG). HG has been stigmatized and neglected by the biomedical community, with limited research funding for developing effective treatments. In this episode of Beyond the Abstract, Derek and Dan tell the remarkable story of one scientist who experienced HG herself, and her decades-long journey to find a cure. Articles discussed Her Doctor Said Her Illness Was All in Her Head. This Scientist Was Determined to Find the Truth. Alice Callahan. New York Times, 2023. ( https://www.nytimes.com/2023/03/14/well/marlena-fejzo-hyperemesis-gravidarum.html ) GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Fejzo et al. 2023. Nature. ( https://www.nature.com/articles/s41586-023-06921-9 ). Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Fejzo et al. 2018. Nature Communications. ( https://www.nature.com/articles/s41467-018-03258-0 ) The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 The Way of Wegovy Part 2: Obesity Treatment and New Frontiers 22:53
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A new class of medicines has transformed the treatment of obesity -- Wegovy and Ozempic have become household names. While we discussed these GLP-1 medicines on an episode of Beyond the Abstract less than a year ago, the field has progressed so quickly we thought it was already time to review many of these recent developments. In today's episode, Derek and Dan first discuss improved versions of these medicines on the horizon for the treatment of obesity. Derek and Dan then talk about how these medicines are being studied to treat a wide range of diseases outside of obesity, ranging from cardiovascular disease to substance use disorder. Articles discussed Jastreboff et al 2023 NEJM, Triple-Hormone Receptor Agonist Retatrutide for Obesity -- A Phase 2 Trial ( https://www.nejm.org/doi/full/10.1056/NEJMoa2301972 ) Wharton et al 2023 NEJM, Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity ( https://www.nejm.org/doi/full/10.1056/NEJMoa2302392 ) Lincoff et al 2023 NEJM, Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes ( https://www.nejm.org/doi/full/10.1056/NEJMoa2307563 ) Kosiborod et al 2023 NEJM, Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity ( https://www.nejm.org/doi/full/10.1056/NEJMoa2306963 ) The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 ChatGPT Will See You Now: The Present and Future of AI in Medicine 18:52
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Debates around artificial intelligence are everywhere: will ChatGPT usher in a new era of productivity and creativity? Or will advanced AI replace millions of workers? Doctors have similar questions about how AI may influence medicine. In today's episode of Beyond the Abstract, Dan and Derek take a deep dive into all things AI and health. They discuss the current role of AI in medicine and the promises and perils of potential new applications made possible because of ChatGPT and other emerging AI technologies. Moor et al., Foundational models for generalist medical artificial intelligence, Nature, 2023 ( https://www.nature.com/articles/s41586-023-05881-4 ). He et al., Blinded, randomized trial of sonographer versus AI cardiac function assessment, Nature, 2023 ( https://www.nature.com/articles/s41586-023-05947-3 ). The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
It's well known that emotions can affect the heart - we've all had an anxiety-producing thought that leads to the feeling of our heart pounding out of our chest. But what about the opposite: can the heart control our emotions? In today's episode of Beyond the Abstract, Derek and Dan discuss a fascinating new study looking at whether making the heart beat fast can cause anxiety-related behaviors. Hsueh et al., Cardiogenic control of affective behavioral state, Nature, March 2023 ( https://www.nature.com/articles/s41586-023-05748-8 ) The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 'Cause Baby Now We've Got Bear Blood 19:33
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The effect of inappropriate blood clotting can be devastating, including heart attack and stroke. While there are many medications to reduce the risk of clotting, our understanding of why blood clots and when remains incomplete. In today’s episode of Beyond the Abstract, Derek and Dan share the remarkable story of how a team of researchers discovered new clotting biology, in a story that begins with a surprising observation about hibernating bears and ends with the characterization of a potential new drug target for humans. Thienel et al. Immobility-associated thromboprotection is conserved across mammalian species from bear to human. Science , 2023. The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 The Key Lies with APOE: Unlocking New Treatments for Alzheimer's 16:28
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Alzheimer’s disease is a devastating neurodegenerative condition affecting millions of people around the world. Current therapies are only partially effective, despite decades of research aimed at understanding the causes of the disease. Alzheimer’s is largely genetic, and the best-known genetic risk factor for Alzheimer’s comes from mutations in a gene called APOE. Until recently, however, exactly how these mutations increase risk for the disease has not been well understood. In today’s episode, Dan and Derek discuss new research on how mutations in APOE leads to Alzheimer’s disease. They talk about the new biological pathways uncovered, the potential therapeutic potential of the discovery, and a related early-stage clinical trial of gene therapy in Alzheimer’s disease. Blanchard et al., APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes. Nature , November 2022. DOI: https://doi.org/10.1038/s41586-022-05439-w The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 The Way of Wegovy: A New Drug for Weight Loss 14:41
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Approximately four in 10 Americans are obese, putting millions at increased risk of developing diabetes, heart disease, liver cancer, and other chronic illnesses. For many years it’s seemed that we’re losing the battle against this modern epidemic. However, the tide may be turning with the recent approval of a revelatory new class of medications. In today’s episode, Dan and Derek dive deep into this new type of treatments. They discuss their discovery, the biology behind them, the pivotal clinical trials showing their efficacy, and the promises and perils of this powerful new tool in the fight against obesity. Wilding et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. The New England Journal of Medicine, March 2021. DOI: 10.1056/NEJMoa2032183 The information presented here is not medical advice. Consult your physician for any questions regarding your personal health.…
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1 BTS on BTA: Answering Your Questions! 32:47
32:47
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Our episode today takes us Behind The Scenes (BTS) on Beyond The Abstract (BTA). Derek and Dan answer your questions on graduate school on everything from how we chose our research topics, how we deal with imposter syndrome and stress, how it feels to have finished our PhDs, and more! We hope you enjoy this change from our usual format. If you have questions you'd like us to answer, DM us @btapod on Instagram!…
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1 Runnin' for Clusterin: Exercise Improves Cognition 13:00
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This episode is sponsored by Proteintech. Exercise is good for us - it keeps off the pounds and decreases our risk for heart attack and diabetes. What may be less known about exercise is that it's actually also good for the brain. Exercise improves memory and learning, and may even improve brain function in people with Alzheimer's disease. However, it's not know how exercise might exert these beneficial effects on the brain. In today's episode, Derek and Dan discuss a paper where researchers have identified a molecule called 'clusterin' in blood that seems to improve brain function. They also talk about how Proteintech is contributing to groundbreaking research like this through high quality antibodies and reagents. De Miguel et al. Exercise plasma boosts memory and dampens brain inflammation via clusterin. Nature, December 2021. DOI: 10.1038/s41586-021-04183-x The information presented here is not medical advice. Consult your physician on any questions regarding your personal health.…
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1 The Placenta: Here for a Good Time, Not a Long Time 16:20
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Preeclampsia is a pregnancy disorder characterized by high blood pressure and contributes to significant fetal and maternal deaths. However, what exactly causes preeclampsia is unclear. It's thought that preeclampsia is caused by placental dysfunction - specifically, the ability of specialized fetal cells called trophoblasts to replace and remodel maternal blood vessels. In this episode of Beyond the Abstract, Derek and Dan discuss a new paper that describes how trophoblasts "mimic" blood vessels in order to establish the maternal-fetal connection in the placenta and how this process may go awry in preeclampsia. Read more about this research in this blog post . Sung et al. VE-cadherin enables trophoblast endovascular invasion and spiral artery remodeling during placental development. eLife, April 2022. DOI: 10.7554/eLife.77241 The information presented here is not medical advice. Consult your physician on any questions regarding your personal health.…
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