314 - Vascular Changes in Alzheimer's Disease: October 2022

AMiNDR: A Month in Neurodegenerative Disease Research

In this episode, Elyn takes you through 13 papers from October 2022 published on vascular contributions to Alzheimer disease. It's quite the journey through mechanistic mouse studies, neuroimaging studies, and a few studies assessing treatments targeting the vasculature, which all paint a pretty convincing picture of the importance of the cerebrovasculature in brain health. Tune in to learn more about the glymphatic system, consequences of amyloid deposition on the vasculature, and a clinical study testing out albumin replacement as an AD treatment!

Sections in this episode:

Vascular Implications of Amyloid Accumulation (3:52)

Glymphatic System (7:31)

Other Clinical Studies (10:57)

Co-morbidities and Risk Factors (15:20)

Treatment Avenues (22:15)

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To find the numbered bibliography with all the papers covered in this episode, click here, or use the link below:

https://drive.google.com/file/d/1I1UBwfShuf9D9GH9mkGZJd2HkQzNt65v/view?usp=share_link

To access the folder with ALL our bibliographies, follow this link (it will be updated as we publish episodes and process bibliographies), or use the link below:

https://drive.google.com/drive/folders/1bzSzkY9ZHzzY8Xhzt0HZfZhRG1Gq_Si-?usp=sharing

You can also find all of our bibliographies on our website: amindr.com.

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Email: [e-mail]

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Please help us spread the word about AMiNDR to your friends, colleagues, and networks! And if you could leave us a rating and/or review on your streaming app of choice (Apple Podcasts, Spotify, or wherever you listen to the podcast), that would be greatly appreciated! It helps us a lot and we thank you in advance for leaving a review! Don’t forget to subscribe to hear about new episodes as they come out too.

Thank you to our sponsor, the Canadian Consortium of Neurodegeneration in Aging, or CCNA, for their financial support of this podcast. This helps us to stay on the air and bring you high quality episodes. You can find out more about the CCNA on their website: https://ccna-ccnv.ca/.

Our team of volunteers works tirelessly each month to bring you every episode of AMiNDR. This episode was scripted and hosted by Elyn Rowe, edited by Scott Prins, and reviewed by Cassi Friday and Anusha Kamesh. The bibliography and wordcloud were created by Lara Onbasi (www.wordart.com).

Big thanks to the sorting team for taking on the enormous task of sorting all of the Alzheimer’s Disease papers into episodes each month. For October 2022, the sorters were Sarah Louadi, Eden Dubchak, Ben Cornish, Christy Yu, Dana Clausen, Kevin Nishimura, Salodin Al-Achkar, and Elyn Rowe. Also, props to our management team, which includes Sarah Louadi, Ellen Koch, Naila Kuhlmann, Elyn Rowe, Anusha Kamesh, Lara Onbasi, Joseph Liang, and Judy Cheng, for keeping everything running smoothly.

Our music is from "Journey of a Neurotransmitter" by musician and fellow neuroscientist Anusha Kamesh; you can find the original piece and her other music on soundcloud under Anusha Kamesh or on her YouTube channel, AKMusic.

https://www.youtube.com/channel/UCMH7chrAdtCUZuGia16FR4w

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If you are interested in joining the team, send us your CV by email. We are specifically looking for help with sorting abstracts by topic, abstract summaries and hosting, audio editing, creating bibliographies, and outreach/marketing. However, if you are interested in helping in other ways, don't hesitate to apply anyways.

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*About AMiNDR: *

Learn more about this project and the team behind it by listening to our first episode: "Welcome to AMiNDR!"