A podcast for those wanting to learn more about health conditions and the personal experience.
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IRON-MATTERS is a series of interviews by and for medical and health practitioners focusing on hereditary haemochromatosis. The series is intended to provide general practitioners with in-depth information about this genetic chronic condition. Topics include - diagnosis in general practice with GP Dr Robert Menz- the genetics of haemochromatosis with clinical geneticist Prof martin Delatycki- haemochromatosis and the liver with gastroenterologist Prof John Olynyk- haemochromatotic arthropath ...
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The Blood Podcast summarizes content recently published in Blood, the most cited peer-reviewed publication in the field of hematology.
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CD8+ T-cell differentiation and treatment response in AML; ATM germline pathogenic variants affect cancer outcomes in ataxia-telangiectasia; efficacy of a selective menin-KMT2A inhibitor in KMT2A- and ...
22:42
22:42
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22:42
In this week's episode we’ll discuss how CD8+ T-cell differentiation and dysfunction inform treatment response in acute myeloid leukemia; learn more about the effect of ATM germline pathogenic variants on the outcomes in children with ataxia-telangiectasia and hematological malignancies; and discuss the preclinical efficacy of a potent, selective m…
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Episode 30: Parkinson’s Disease - The Shaking Palsy
19:37
19:37
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19:37
Parkinson's Disease: What is it? What are the symptoms? How is it treated? In this episode, we will explore the history, the neurotransmitter associated with Parkinson's disease, and the methods for diagnosing the condition. Tune in to learn more! Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoff…
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TCR-T cells for post-HCT leukemia recurrence; platelets are the predominant source of procoagulant membranes in hemostasis; BR + R maintenance for MCL
18:10
18:10
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18:10
In this week's episode we'll discuss HA-1-targeted T-cell receptor T-cell therapy for recurrent leukemia after hematopoietic stem cell transplantation. Next, we'll learn about how 4D intravital imaging in mice reveals the key role of platelets as a source of procoagulant membranes in hemostasis. Finally, we'll hear about modifications to a common i…
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Episode 29: Rickets - Another Disease of the Medici Family
13:28
13:28
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13:28
Rickets: What is it? What are the symptoms, and what causes it? In this episode, we will explore the history of rickets, its causes, and the treatment. Tune in to learn more! Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com/anatomyofix Resources Bone Health Foundation (AUS): https://www.bo…
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Outcomes of younger patients with mantle cell lymphoma; M-protein assessment during maintenance therapy in multiple myeloma; in vivo CAR T-cell generation using lentiviral vectors
0:59
0:59
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0:59
In this week's episode we’ll discuss the outcomes of younger patients with mantle cell lymphoma experiencing late relapse; learn more about mass spectrometry-based assessment of M-protein in peripheral blood during maintenance therapy in multiple myeloma and discuss in vivo CAR T-cell generation in non-human primates using lentiviral vectors. Featu…
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Introduced by Associate Editor Dr. Thomas Ortel, this bonus episode discusses the Review Series on Factor XI, published in volume 143 issue 15 of Blood Journal. Dr. Ortel is joined by contributing authors Owen McCarty, PhD, Gili Kenet, MD, and David Gailani, MD. Review Series Articles: Introduction to a review series on factor XI Biology of factor …
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Episode 28: Dermatitis - A Humour’s Boiling Point
13:30
13:30
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13:30
Dermatitis: What is it? How is it treated? What causes it? In this episode, we will explore the history, different types of dermatitis and eczema, and their symptoms. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com/anatomyofix Resources National Eczema Associatio…
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Protective role of neonatal CMV infection in B-ALL; GVHD targets organoid-forming bile duct stem cells; seven-year outcomes for venetoclax-ibrutinib therapy in MCL
16:56
16:56
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16:56
In this week's episode we'll learn how cytomegalovirus infection early in life depletes preleukemic cells in a mouse model of B-cell acute lymphoblastic leukemia. After that we'll discuss new research, where GVHD targets organoid-forming bile duct stem cells in a TGF-beta-dependent manner. Conversely, a TGF-beta inhibitor protects these stem cells …
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Episode 27: Hirschsprung’s Disease - Where’s the Meconium?
10:46
10:46
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10:46
Hirschsprung’s Disease: What is it? What are the risk factors? What are the symptoms? In this episode, we will delve into the history, diagnosis, and treatment of Hirschsprung’s disease. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com/anatomyofix Resources Reach …
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Iron, HFE haemochromatosis, and infections; bispecific antibodies improve CAR T-cell response; determinants of outcome in NPM1-mutated AML
23:31
23:31
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23:31
In this week's episode we'll learn about iron, HFE hemochromatosis, and infections. In this large, population-based study, both high and low levels of plasma iron and transferrin saturation were associated with increased risks of infection. Then, we'll discuss how bispecific antibodies improve CAR T-cell response in B-cell malignancies. In-vitro an…
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Episode 26: Diabetes Mellitus - Sweet, Sweet Water
16:42
16:42
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16:42
Diabetes Mellitus: What are the symptoms? What are the causes? And what is the difference between type 1 and type 2? In this episode, we will explore the history of diabetes, how it is tested, and how it is treated. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com…
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Immune fitness and response to taclistamab in R/R multiple myeloma; BCR::ABL1 M244V mutation causes resistance to asciminib; HSCT and myocardial fibrosis in young patients with SCD
16:59
16:59
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16:59
In this week's episode we’ll discuss how immune fitness impacts response to teclistamab in relapsed/refractory multiple myeloma; learn more about a new mechanism of resistance to asciminib conferred by the BCR::ABL1 M244V mutation, and discuss the impact of hematopoietic cell transplantation on myocardial fibrosis in young patients with sickle cell…
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Episode 25: Polycystic Ovarian Syndrome - Pigeon Eggs or Almonds?
13:46
13:46
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13:46
Polycystic Ovarian Syndrome: What is it, how is PCOS diagnosed, and what are its symptoms? In this episode, we will explore the history, current knowledge, and management of this condition. Tune in to learn more. Check out our website: https://anatomyofillness.com/ Support us on Buy Me a Coffee: https://buymeacoffee.com/anatomyofix Resources: PCOS …
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Decitabine in older patients with AML; EPCR and sickle chronic kidney disease; lymphocyte depletion versus post-transplant cyclophosphamide for mismatched donor transplant for inborn errors of immunity ...
22:53
22:53
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22:53
In this week's episode we’ll discuss the safety and efficacy of decitabine in older patients with AML; learn how heme-induced loss of renovascular endothelial protein C receptor promotes chronic kidney disease in sickle mice, and discuss the outcomes of treatment with HLA-mismatched HSCT with TCRab/CD19 lymphocyte depletion or post-HSCT cyclophosph…
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Episode 24: Retinitis Pigmentosa - Morbus Arianus
12:45
12:45
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12:45
Retinitis Pigmentosa: What causes it? Do we have a cure or treatment for it? What are the symptoms of it? In this episode, we will explore the causes, symptoms, and delve into the history of the condition. We will also discuss how it is diagnosed and take a brief look into blindness. Check out our website: https://anatomyofillness.com/ Molly Burke …
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Impact of MRD-negative on PFS in myeloma; IPSS-R down-staging before transplant in MDS; hereditary angioedema and venous thromboembolism
21:50
21:50
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21:50
In this week's episode we'll discuss minimal residual disease as an intermediate clinical endpoint for multiple myeloma. Then, we'll learn about IPSS-R downstaging before transplant in MDS. Finally we'll hear about the connection between hereditary angioedema and venous thromboembolism. Featured Articles: EVIDENCE meta-analysis: evaluating minimal …
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Episode 23: Polycystic Kidney Disease - a 350 Year Mystery
10:18
10:18
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10:18
Polycystic Kidney Disease: What do a Polish King and an American playwright have in common? What are the symptoms of PKD, and how do we treat it? In this episode, we delve into the history, symptoms, and causes of PKD. Tune in to find out more! Check out our website: https://anatomyofillness.com/ PKD Foundation (US): https://pkdcure.org/ PKD Charit…
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Acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; alternative donor transplantation for severe aplastic anemia; clonal relapse dynamics in AML following allogeneic HCT
23:32
23:32
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23:32
In this week's episode we’ll discuss the safety and efficacy of acalabrutinib, venetoclax and obinutuzumab in relapsed/refractory CLL; learn more about alternative donor transplantation for severe aplastic anemia and discuss clonal relapse dynamics in acute myeloid leukemia following allogeneic hematopoietic cell transplantation. Featured Articles:…
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Episode 22: Haemochromatosis - The Viking Disease
12:32
12:32
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12:32
Haemochromatosis: What is it, what are the symptoms, and how is it treated? This episode will explore the history, cause, and treatment of Haemochromatosis. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Iron Disorders Institute (USA): https://irondisorders.org/about-idi/ Haemochromatosis UK: https://www.haemochromat…
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Clinical impact of CRh in AML; thrombosis features in a real-life PNH cohort; and restriction of SOX11 expression to EBV-negative Burkitt lymphomas
19:58
19:58
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19:58
In this week's episode we'll learn about the clinical benefit of complete remission with partial hematological recovery, or CRh, in patients with Acute Myeloid Leukemia (AML) treated with molecularly targeted drugs. Then we'll hear about a large cohort of patients with PNH were studied to detail PNH-related thrombotic events, unravel determinants o…
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Episode 21: Crohn's Disease and Ulcerative Colitis - Tuberculosis in my What?
13:51
13:51
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13:51
Crohn’s disease and ulcerative colitis: What are they? What are the symptoms, and how do they differ? In this episode, we will explore the historical background, our current understanding of these conditions, and their treatments. Tune in to learn more. Check out our website: https://anatomyofillness.com/ Crohn’s and Colitis Foundation (US): https:…
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Mutational and transcriptional landscape of pediatric BCP lymphoblastic lymphoma; the role of platelet-derived TGF-1 in immune thrombocytopenia; phase 3 trial of mavorixafor in WHIM syndrome
23:25
23:25
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23:25
In this week's episode we’ll discuss the mutational and transcriptional landscape of pediatric BCP lymphoblastic leukemia; learn more about the role of platelet-derived TGF-β1 in immune thrombocytopenia; and discuss the findings from a phase 3 trial of mavorixafor in WHIM syndrome. Featured Articles: Mutational and transcriptional landscape of pedi…
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Episode 20: Allergies and Anaphylaxis - What is Food to Some is Poison to Others
15:04
15:04
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15:04
Allergies: What are they, what are the symptoms, and how do we treat them? In this episode, we delve into the causes of allergies, their history, and diagnosis methods. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Rubin_Allergy: https://www.instagram.com/rubin_allergy?igsh=eHhsaDhsempkZjh5 Movies featuring allergie…
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GM-CSF coordinates shelter in the cytokine storm; Interleukin-1 as a therapeutic target in TTP; CAR T-cell outcomes across race and ethnicity in LBCL
19:57
19:57
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19:57
In this week's episode we'll discuss new insights on the role of GM-CSF in establishing immune memory. The authors propose that the coordination of opposing immune memory programs, driven by GM-CSF, may be essential to efficient, yet controlled, innate immune responses. After that: Interleukin-1 inhibition in TTP. Researchers explore the potential …
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Review Series on Oncogenic Signaling and Immune Evasion in Hematologic Malignancies
15:41
15:41
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Introduced by Associate Editor Robert Zeiser, this Review Series focuses on the problem of immune escape by acute myeloid leukemia (AML). The series opens with a review of how AML escapes T-cell–driven elimination and then focuses on how p53 function impinges on AML recognition by immune cells. The series finishes with a summary of new approaches t…
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Episode 19: Epilepsy - Not Caused by the Bad Spirits
25:38
25:38
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25:38
Epilepsy: What is it, what are the symptoms, and how do we diagnose it? In this episode, we will delve into the cause of epilepsy, its history, and how we treat it. Tune in to find out more. Check out our website: https://anatomyofillness.com/ Epilepsy Foundation (US): https://www.epilepsy.com/ Epilepsy Foundation (AUS): https://epilepsyfoundation.…
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Reassessing the CLL prognostic index; ADAMTS13 conformation and risk of relapse in immune-mediated TTP; haploidentical bone marrow transplant in sickle cell disease
23:39
23:39
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23:39
In this week's episode we’ll discuss the prognostic value of the Chronic Lymphocytic Leukemia International Prognostic Index in the era of targeted therapies, learn how peak ADAMTS13 activity can be used to assess ADAMTS13 conformation and risk of relapse in immune-mediated thrombotic thrombocytopenic purpura, and discuss the findings from a phase …
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Episode 18: Chronic Obstructive Pulmonary Disease - Not Just for Smokers
13:51
13:51
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13:51
Chronic Obstructive Pulmonary Disease (COPD): What is it, what are the symptoms, and how do we treat it? In this episode, we discuss the two main conditions involved in COPD, who is at risk for it, and the history of the condition. Check out our website: https://anatomyofillness.com/ COPD Foundation (US): https://www.copdfoundation.org/ Asthma and …
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A biomarker for disease severity in Wiskott-Aldrich Syndrome; loss of Dnmt3a confers resistance to IFNα; unrelated donor selection in HSCT with PTCy
19:16
19:16
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19:16
In this week's episode we'll discuss assessing risk profile in Wiskott-Aldrich Syndrome, or WAS. Then, we'll learn about how the loss of DNMT3A confers resistance to interferon-alpha in hematopoietic stem cells carrying the JAK2-V617F mutation. Finally, we'll explore unrelated donor selection for AML patients undergoing hematopoietic stem cell tran…
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Episode 17: Duchenne Muscular Dystrophy - Calves that Aren’t from the Gym
15:03
15:03
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15:03
Duchenne Muscular Dystrophy: What is it, what are the symptoms, and how do we treat it? This episode will cover the history, genetics, and testing for Duchenne Muscular Dystrophy. Check out our website: https://anatomyofillness.com/ Muscular Dystrophy Association: https://www.mda.org/ Duchenne UK: https://www.duchenneuk.org/ Duchenne Australia: htt…
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Nilotinib with or without cytarabine for Philadelphia-positive AML; thrombosis risk in Factor V Leiden and Prothrombin G20210A; ctDNA improves prognostic prediction in relapsed/refractory multiple myeloma ...
23:05
23:05
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23:05
In this week's episode we’ll discuss the safety and efficacy of nilotinib with or without cytarabine in Philadelphia-positive acute lymphoblastic leukemia; learn more about thrombosis risk in double heterozygous carriers of Factor V Leiden and prothrombin G20210A and discuss the utility of circulating cell-free tumor DNA in prognostic prediction in…
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Episode 16: Graves’ Disease - The Thyroid, Not for Worms
18:32
18:32
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18:32
Graves' Disease: What is it? What are the symptoms? In this episode, we will delve into the history of Graves' Disease, diagnosis methods, treatment options, and its underlying causes. Tune in to find out more. Check out our website: https://anatomyofillness.com/ British Thyroid Foundation: https://www.btf-thyroid.org/ Graves Disease And Thyroid Fo…
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Hemophilia prophylaxis with fitusiran vs BPA/CFC; germline NBN variants in pediatric B-ALL; Histone demethylation and cell-intrinsic immune response in AML
18:59
18:59
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18:59
In this week's episode we'll learn about fitusiran prophylaxis in patients with hemophilia A or B, with or without inhibitors. Next we'll hear about new findings that heterozygous germline variants in the NBN gene that are linked to increased risk of B-cell acute lymphoblastic leukemia in children. Finally, we'll explore new insights on the histone…
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Episode 15: Sickle Cell Anaemia - Not the Regular Anti-Malarial
17:59
17:59
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17:59
Sickle cell anaemia: What is it? What are its symptoms and genetics? In this episode, we will explore the history, treatment, and the reasons behind the existence of this condition. The episode will also explain the potential complications associated with sickle cell anaemia. Tune in to find out more. Check out our website: https://anatomyofillness…
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Effects of voxelotor on cerebral blood flow in pediatric sickle cell disease; thrombosis in Vexas syndrome; response to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia
22:26
22:26
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22:26
In this week's episode we’ll discuss the effects of voxelotor on cerebral blood flow in pediatric sickle cell disease, learn more about venous and arterial thrombosis in patients with Vexas syndrome, and discuss differential sensitivity to tyrosine kinase inhibitors in ABL-class acute lymphoblastic leukemia. Featured Articles: The influence of voxe…
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Episode 14: Addison's Disease - Giving me an Adrenal Crisis
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21:02
Addison's disease, what are the symptoms, and how do we test for it? In this episode, we go over the history that led to the discovery of Addison's disease, its causes, how we treat it, and some of the famous cases. A massive thanks to @leo_adrenal_insufficiency on Instagram for helping with this episode! Check out our website https://anatomyofilln…
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Stamping out high-risk myeloma with D-KRd and tandem transplant; plasmin-cleaved VWF in microthrombosis; SCD plasma sensitizes iPSC-derived sensory neurons
19:40
19:40
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19:40
In this week's podcast we'll discuss another step forward in stamping out high-risk myeloma. Then we'll hear about the plasmin-cleaved von Willebrand factor, or VWF, in microthrombosis. Finally we'll hear about new insights into the origins of sickle cell pain. Featured Articles: Daratumumab, carfilzomib, lenalidomide, and dexamethasone with tandem…
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Episode 13: Breast Cancer - One in Eight
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23:59
Breast cancer: What are the symptoms, and how common is it? This episode covers its history, risk factors, diagnostic tests, and much more. Check out our website: https://anatomyofillness.com/ Susan G Komen Foundation screening tools page: https://www.komen.org/breast-cancer/risk-factor/understanding-risks/gail-method/ American Breast Cancer Founda…
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Allogeneic transplant in first remission for post-induction molecular MRD; circulating HSPCs actively participate in human hematopoiesis; let-7 miRNAs repress HIC2 to regulate BCL11A transcription and ...
21:44
21:44
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21:44
In this week's episode we’ll discuss the utility of MRD in identifying patients with NPM1 AML who benefit from allogeneic transplant in first remission, learn more about the contribution of circulating hematopoietic stem/progenitor cell subsets to human hematopoietic hemostasis, and discuss the role of Let-7 miRNAs in regulation of BCL11A transcrip…
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Episode 12: Achondroplasia - Not Caused by Wine Cults
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11:09
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11:09
Achondroplasia, what actually is it and how is it inherited? In this episode we go over achondroplasia throughout the times, including the belief of it being associated with an ancient wine cult, the genetics and diagnosis, as well as potential treatment options that are offered today. Check out our website: https://www.anatomyofillness.com/ If you…
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ADAMTS13 recovery in caplacizumab-treated TTP; inhibition of venetoclax-resistant BCL2 variants with sonrotoclax; genomic insights from Castleman disease in twins
19:10
19:10
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19:10
In this week's epside we'll learn about ADAMTS recovery after caplacizumab therapy in patients with immune thrombotic thrombocytopenic purpura. Then, we'll hear about preclinical characterization of sonrotoclax, a potential second-generation BCL2 inhibitor. Finally we'll hear about new insights into the etiology of Castleman disease where researche…
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Episode 11: Scurvy - An Orange a Day Keeps the Scurvy Away
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18:15
Scurvy, you hear its name and you think of pirates and old sea voyages. So why did pirates get scurvy? Is it an issue we still face today? If so how do we treat scurvy? To find out more about the history of scurvy and where we are with it today, tune into this week's episode! Check out our website: https://anatomyofillness.com/ References: https://…
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Durable response after tisa-cel in adults with relapsed/refractory follicular lymphoma; high microRNA-145 plasma levels indicate decreased risk of VTE; epigenetic/immunogenetic signature in the prediction ...
23:49
23:49
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पसंद
23:49
In this week's episode, we’ll discuss the findings from a study assessing responses after treatment with tisagenlecleucel [LM1] in adults with relapsed/refractory follicular lymphoma, learn more about the association between high microRNA-145 plasma levels and decreased risk of future incident venous thromboembolism, and discuss how epigenetic and …
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Episode 10: Coeliac disease - Not a Diet Trend
16:26
16:26
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पसंद
16:26
What is coeliac disease, and how long has it existed? In this episode we discuss the condition in the mouths of many talk show hosts and painted incorrectly in the show “Do Revenge”. Tune in to learn the truth behind this autoimmune condition, and why it is not just a trend. Check out our website: https://anatomyofillness.com/ If you're interested …
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Gut microbiota exploitation by CPX-351 in AML; optimizing anti-myeloma immunity for ASCT; which pediatric ITP patients will develop lupus?
19:00
19:00
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19:00
In this week's episode, we'll discuss gut microbiota exploitation by CPX-351 in acute myeloid leukemia. Then we'll learn about optimizing anti-myeloma immunity. New research shows that regulatory T cells suppress myeloma-specific immunity during autologous stem cell mobilization and transplantation. Finally we'll discuss among pediatric patients wi…
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Episode 9: Scoliosis - But have you tried Ladder Τherapy?
21:45
21:45
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21:45
Scoliosis, what is it? An age old question that we have been trying to solve for centuries. Because of this, we have centuries of scoliosis medical devices, such as bracing or old exercise devices, with good intent but not always good results. Tune into this week's episode to find out about what we currently know about Scoliosis and how we currentl…
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Jak2V617F clonal hematopoiesis promotes arterial thrombosis; Staphylococcus aureus infection in Sézary syndrome; clinical features of RAC2-related immunodeficiency
26:18
26:18
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पसंद
26:18
In this week's episode we’ll discuss the mechanism by which Jak2V617F clonal hematopoiesis promotes arterial thrombosis, discuss how Staphylococcus aureus induces drug resistance in cancer T cells in Sézary syndrome, and learn more about the clinical and functional features of RAC2-related immunodeficiency. Featured Articles: Jak2V617F clonal hemat…
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Episode 8: Kawasaki disease - Not your normal Childhood Sniffles
17:48
17:48
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17:48
Have you ever wondered what Kawasaki Disease is? What are the symptoms and why is it so dangerous? Tune in to this week's episode to find out about the history, symptoms and treatment of Kawasaki Disease as well as some interesting little tidbits. Check out our website: https://anatomyofillness.com/ If you're interested in Kawasaki Disease Foundati…
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Molecular mimicry in aplastic anemia; emicizumab prophylaxis in infants with hemophilia; hydroxyurea reduces infections in SCA
19:54
19:54
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पसंद
19:54
In this week's episode we'll discuss molecular mimicry in aplastic anemia, novel experiments show that antigens associated with viral infections can mimic epitopes presented on hematopoietic progenitor cells. Then, we'll learn about prophylaxis with subcutaneous emicizumab in infants with hemophilia. Finally we'll see how hydroxyurea is associated …
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Episode 7: Pheochromocytoma - You’re giving me an Adrenaline Rush
17:39
17:39
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17:39
Pheochromocytoma, you may have heard this term thrown around in your favourite medical show, but how much do you know about it. What are the symptoms of pheochromocytoma, how do we diagnose it, how do we treat it, and how long have known about its existence? Which US president had it? Tune into this week's episode to find out. Check out our website…
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