Working Together for Better Patient Care: Alpha Clinic Directors Panel - Sanford Stem Cell Symposium 2023

Stem Cell Channel (Audio)

Stem Cell Channel (Audio)

30:21

Hitting plateaus is a common milestone in business, but there’s a difference between stability and a rut. In the last installment of this season, we’ll dive into the ways small business owners push beyond plateaus and find new ways to achieve revenue growth. Jannese and Austin wrap up their time in Nashville, Tennessee with a wonderful visit to N.B. Goods to speak with owner Camille Alston . Camille details the times where she hit a wall with profits, the strategies she implemented to increase revenue, what worked, what didn’t, and the important lessons she learned in the process. You won’t want to miss this informative final chapter! Learn more about how QuickBooks can help you grow your business: QuickBooks.com See omnystudio.com/listener for privacy information.…

about a year ago 56:27

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CIRM-funded Alpha Stem Cell Clinics are a network of California medical centers that specialize in delivering stem cell clinical trials to patients. In this fascinating panel, clinic directors discuss advanced treatments, therapies like gene editing, and sharing knowledge and creating networks across the country for better patient care. Featuring: Geoffrey Lomax, Dr.PH California Institute for Regenerative Medicine Esther and Andrew Schorr Patient Advocates Sandra Dillon Cancer Survivor and Stem Cell Champion Catriona Jamieson, M.D., Ph.D. UC San Diego Mehrdad Abedi, M.D. UC Davis Daniela A. Bota, M.D., Ph.D. UC Irvine Sheila Chari, Ph.D. Cell Press Leo D. Wang, M.D., Ph.D. City of Hope National Medical Center Mark Walters, M.D. University of California, San Francisco Thomas Buchanan, M.D. University of Southern California Michael Lewis, M.D. Cedars Sinai Noah Federman, M.D. UCLA Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39070]

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#Science #UCTV

Working Together for Better Patient Care: Alpha Clinic Directors Panel - Sanford Stem Cell Symposium 2023

published about a year ago

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MP3•एपिसोड होम

100 एपिसोडस

#Science #UCTV

सभी एपिसोड

1
Stem Cells Scientific Publishing - Sanford Stem Cell Symposium 2024 58:38

9 weeks ago58:38

58:38

Karen Christman, Sheila Chari, Stella Hurtley, and Robert Stephenson explore academic publishing in stem cell research, focusing on reproducibility, collaboration, and public communication. Editors from top journals discuss curating impactful research, sharing clinical trial data, and addressing challenges in scaling and standardizing therapies. They emphasize bridging silos, advancing precision regenerative medicine, and navigating open access publishing to responsibly propel the field forward. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39940]…

1
The Future of Precision Medicine: Stem Cells Gene Therapy and AI - Medicine Informing Novel Discoveries (MIND) 57:36

12 weeks ago57:36

57:36

Learn about advancements in precision medicine, particularly the role of AI, stem cell research, and gene therapy. Experts highlight AI’s potential in personalized treatments, diagnostics, and patient care. Key topics include RNA targeting therapies, base editing for gene mutations, and using stem cells for disease modeling and regeneration. AI’s contribution to enhancing healthcare efficiency and decision-making is also explored, emphasizing its role in personalized medicine through large data sets. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39981]…

1
Uncovering Mechanisms of Neurodegenerative Diseases by CRISPR-Based Screens with Martin Kampmann 58:22

15 weeks ago58:22

58:22

Martin Kampmann, Ph.D., explores how CRISPR screening and induced pluripotent stem cell (iPSC) technology can uncover new insights into neurological diseases such as Alzheimer's. His lab uses CRISPR to identify genes that influence protein aggregation and cellular vulnerability, focusing on neurons, astrocytes, and microglia derived from human stem cells. Kampmann highlights the roles of mitochondria, autophagy, and other cellular pathways in disease progression, emphasizing the importance of understanding both protective and damaging processes. He also discusses the potential contributions of glial cells—especially microglia and astrocytes—to neurodegeneration, sparking ideas for therapeutic targets. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39461]…

1
A Closer Look at…Stem Cells and the Human Brain 57:28

17 weeks ago57:28

57:28

Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A., discuss exciting advancements in brain cancer research, focusing on glioblastoma, an aggressive and challenging tumor. They highlight how specific genetic mutations drive tumor growth and how targeting these mutations could lead to new treatments. They also delve into cutting-edge therapies, including using light to activate drugs aimed at combating cancer. A central theme of the talk is the complexity and ever-changing nature of these tumors, which makes them difficult to treat. However, technological breakthroughs, like single-cell genetic sequencing and lab-grown tumor models, are providing scientists with valuable insights into tumor behavior, paving the way for more personalized and effective treatment options in the future. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39871]…

1
A Tale of Two Barriers: Plasticity of Lung Epithelium and Mesothelium 58:40

18 weeks ago58:40

58:40

Le Xu, Ph.D., examines the intricate processes underlying lung development and disease, with a focus on idiopathic pulmonary fibrosis (IPF). Xu explores the roles of genetic and cellular mechanisms, including the hedgehog pathway, FGF signaling, and epithelial-mesenchymal interactions, in driving lung fibrosis. Xu also highlights links between congenital diaphragmatic hernia (CDH) and lung development, suggesting that both mechanical and genetic factors contribute to lung hypoplasia. The discussion includes the development of advanced mouse models that replicate key aspects of human IPF, offering insights into fibrosis progression. Xu's research ultimately seeks to identify the causes of lung tissue abnormalities and pave the way for targeted therapies. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39460]…

1
Restoration of T Cell Development in CD3δ SCID Through Adenine Base-Editing with Gloria Yiu - Sanford Stem Cell Symposium 2024 28:12

20 weeks ago28:12

28:12

Gloria Yiu, M.D., Ph.D., delves into the transformative potential of genetic editing technologies in addressing rare immune disorders, with a focus on CD3δ severe combined immunodeficiency (SCID)—a condition characterized by impaired T-cell development and severely compromised immune function. Leveraging her expertise as a physician-scientist, Yiu explores how CRISPR and other precision gene-editing tools can correct genetic mutations at the cellular level, potentially restoring T-cell production and immune resilience in patients with CD3δ SCID. Her presentation underscores the challenges and breakthroughs in treating such life-threatening conditions, emphasizing the role of interdisciplinary research, clinical innovation, and ethical considerations in advancing the frontiers of personalized medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 40245]…

1
Infectious Disease Breakthroughs - Medicine Informing Novel Discoveries (MIND) 56:10

20 weeks ago56:10

56:10

The infections disease landscape is constantly changing - challenging our standard treatments. Can new - as well as ancient - therapies be the answer? Hear from experts on the cutting edge of phage therapy, HIV/AIDS research and cancer care about what is on the horizon to improve human health. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39982]…

1
What Makes a Stem Cell a Stem Cell and How Does it Go Bad? with John Dick - Sanford Stem Cell Symposium 2024 45:32

21 weeks ago45:32

45:32

John Dick, Ph.D., F.R.S., explores the role of CD83, a molecule found in blood stem cells, in how these cells respond to inflammation. His team demonstrates that CD83 becomes highly active during inflammation and contributes to the loss of healthy stem cells. Using advanced gene-editing tools, they show that removing CD83 protects stem cells from inflammation-related damage. This discovery highlights CD83 as a potential marker for identifying inflamed stem cells and as a possible target for treatments to improve recovery after stem cell transplants. He also discusses early findings on potential differences in blood stem cell behavior between men and women and raises questions about how inflammation from severe illnesses, like COVID-19, could impact the blood system as we age. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39949]…

1
Space-Based Research: Predicting and Preventing Accelerated Stem Cell Aging and Cancer Evolution with Catriona Jamieson - Sanford Stem Cell Symposium 2024 28:29

22 weeks ago28:29

28:29

Catriona Jamieson, M.D., Ph.D., discusses pioneering research on cancer and aging in space environments, highlighting how microgravity accelerates cancer cell growth and leads to stem cell exhaustion, genomic instability, and “dark genome” activation. Using innovative tools like nano-bioreactors and artificial intelligence, her team simulates these effects and tracks cellular changes, uncovering how space’s unique conditions drive mutations and alter cellular behavior. They find that stem cells rapidly proliferate but then become exhausted in space, a process tied to telomere shortening and mitochondrial stress, impacting cell longevity and regenerative potential. Through collaborations with NASA and industry partners, Jamieson’s research aims to develop therapies to counter these effects, offering potential insights for cancer treatment and stem cell health on Earth. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 39948]…

1
Explorations of Telomere Biology in the Context of Human Aging with Elizabeth Blackburn - Sanford Stem Cell Symposium 2024 45:17

23 weeks ago45:17

45:17

Elizabeth Blackburn, Ph.D., examines the relationship between telomeres, cellular aging, and metabolic health, highlighting how telomere regulation differs between insulin-sensitive and insulin-resistant individuals. She discusses the effects of environmental factors—like glucose levels, stress hormones, and drugs—on telomere maintenance, which can disrupt cellular coordination and contribute to age-related diseases. Blackburn also shares insights from studies on hibernating lemurs, indicating that while their telomere health remains stable during metabolic slowdowns, it declines upon reactivation. Ultimately, she suggests that telomere maintenance could serve as a valuable biomarker for early signs of metabolic dysfunction, informing strategies for long-term health and resilience. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39944]…

1
Found in Translation: Development of a Cellular Therapy for Age-Related Macular Degeneration 1:12:41

24 weeks ago1:12:41

1:12:41

Dennis O. Clegg, Ph.D., discusses treatments for age-related macular degeneration (AMD), a condition that causes vision loss. Clegg explains that while patients often report improved vision after receiving implants, objective tests don't always confirm this. He explores the potential differences in patients' responses based on genetics and disease progression. There is also an ongoing challenge in finding the best ways to reduce immune rejection of these treatments. New trials are underway to test implants in earlier stages of the disease, and researchers are looking at different strategies like localized immunosuppression. Additionally, some studies suggest that secretions from retinal cells may help preserve vision. Overall, there are many open questions, but advances in the field offer hope for better AMD treatments. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39459]…

1
Unlocking the Secrets of Aging and Longevity with Stem Cells 20:48

25 weeks ago20:48

20:48

Curious about the secret to staying young? Rob Signer shares insights into how our bodies age, focusing on the role of stem cells and a critical protein called HSF1 that helps them cope with stress. Signer explores the delicate balance of keeping these cells healthy without increasing cancer risk and highlighted some promising progress in enhancing the cells' ability to manage waste. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39980]…

1
Stem Cells and the Human Brain - Medicine Informing Novel Discoveries (MIND) 1:04:09

27 weeks ago1:04:09

1:04:09

Explore the captivating realm of brain research at UC San Diego with Frank Furnari, Ph.D., and Alexander Khalessi, M.D., M.B.A. Furnari and Khalessi delve into groundbreaking efforts to find new treatments for neurological conditions such as brain tumors, stroke, and brain injuries, bringing hope to patients and their families. Emphasizing ethics, innovation, and patient care, Furnari and Khalessi shed light on the challenges and successes in their quest to unravel the mysteries of the mind. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39723]…

1
Bioengineering a Kidney Chip for Better Safer and Faster Drug Development 1:11:02

30 weeks ago1:11:02

1:11:02

Catherine Yeung, Pharm.D., Ph.D., M.P.H., discusses groundbreaking advancements in kidney-on-a-chip technology, emphasizing its potential to revolutionize human health. She delves into the role of environmental toxins, such as okra toxin A, microplastics, and plasticizers, in contributing to chronic kidney disease, particularly in regions with specific dietary practices. Yeung also addresses the challenges of replicating adult kidney cells from stem cells, which often retain a fetal phenotype, and underscores the value of stem cell-derived models for genetic manipulation and disease research. Additionally, she highlights the increased risk of kidney stones in astronauts post-spaceflight and the broader implications of organ-on-chip technology for studying therapies and diseases. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39458]…

1
Can Aging be Reversed? Stem Cells as a Key to Longevity 27:32

30 weeks ago27:32

27:32

Curious about what happens to our cells as we age and how it affects our health? Shiri Gur-Cohen explores the role of tiny chemical tags on our DNA, like methylation, in influencing our healing and overall well-being. Gur-Cohen discusses how these tags might be shaped by our body's systems, such as the lymphatic system, and could even help repair or regenerate various parts of our body. Gur-Cohen proposes that uncovering these processes could lead to innovative ways to slow aging or boost our body’s natural healing capabilities. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39979]…

Stem Cell Channel (Audio)

1
Spinal Cord Injury and Plasticity: Breathing After Injury 59:37

32 weeks ago59:37

59:37

Michael Lane, Ph.D., shares his work investigating the effects of cervical spinal cord injury (SCI) on breathing and upper extremity function, focusing on the potential for spontaneous functional recovery, or "plasticity." Lane also discusses efforts to develop and test strategies to promote beneficial plasticity and recovery following cervical SCI, with a particular emphasis on improving respiratory function and activity in respiratory muscles. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39457]…

Stem Cell Channel (Audio)

1
Upgrading the Physiological Relevance of Human Brain Organoids 53:09

34 weeks ago53:09

53:09

Giorgia Quadrato, Ph.D., explores cerebral organoids as models for neural development and disease research. Using live calcium imaging, Quadrato observes increased neuronal coordination attributed to inhibitory neurons, validated through pharmacological and genetic methods. Quadrato contrasts their organoid generation protocol with previous methods, emphasizing complex patterning, long-term cultures, and co-culture with mouse brain cells for improved physiological relevance. Microfluidics are utilized for enhanced oxygenation and physiological conditions. Future efforts focus on incorporating microglial cells for synaptic pruning studies and overcoming challenges in cryopreservation. Overall, the research aims to advance understanding of neural mechanisms and diseases, enhancing organoid fidelity for biomedical applications. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39456]…

Stem Cell Channel (Audio)

1
Modeling Kidney Disease and Regeneration with Organoids Derived from Human Pluripotent Stem Cells 56:20

37 weeks ago56:20

56:20

Benjamin Freedman, Ph.D., delves into the creation and functionality of kidney organoids. He discusses their focus on filtration over hormone functions, and answers intriguing questions about urine characterization and the necessity of organoid structures. Freedman explores the use of scaffolds for implants and ponders the philosophical implications of off-target cells in organoids, questioning whether these cells are a natural part of organ development. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39455]…

Stem Cell Channel (Audio)

1
A Closer Look at...Stem Cells and Human Longevity 58:02

41 weeks ago58:02

58:02

Can we live not only longer but healthier lives? Robert A.J. Signer and Shiri Gur-Cohen explore how stem cell research may unlock the secrets of longevity. Signer discusses the critical role stem cells play in combating aging-related diseases, such as cancer and immune system decline, by boosting their regenerative abilities. His work on hematopoietic stem cells and “super stem cells,” which better manage cellular waste, shows promise for delaying aging and preventing disease. Dr. Shiri Gur-Cohen examines how vascular and lymphatic systems support stem cell health, revealing new strategies for enhancing longevity and reversing the effects of aging. Don’t miss this in-depth look at the future of aging and human health. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39869]…

Stem Cell Channel (Audio)

1
Capturing Late-Onset Neurodegeneration in Patient-Derived Neurons via Direct Reprogramming - Breaking News in Stem Cells 59:16

41 weeks ago59:16

59:16

Andrew Yoo, Ph.D., provides insight into the ongoing research on neurodegeneration and neuronal reprogramming, highlighting the complexities and challenges in modeling and understanding these processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39454]

Stem Cell Channel (Audio)

1
A Closer Look at...Stem Cells in Space 59:56

46 weeks ago59:56

59:56

Why explore stem cells in space when we have the comfort of Earth's laboratories? Join Robert A.J. Signer, Ph.D., alongside Catriona Jamieson, M.D., Ph.D., and Alysson Muotri, Ph.D., as they delve into the untapped potential of space experiments for expediting medical breakthroughs. Patient advocate Alexandria Allen offers a poignant narrative, revealing the profound impact such research has had on her personal health journey. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39733]…

Stem Cell Channel (Audio)

1
Effects of Astrocytic Circadian Clocks Disruption on Synaptic Pruning with Anca Pasca - Breaking News in Stem Cells 55:20

49 weeks ago55:20

55:20

Medical advances have significantly improved the survival of preterm babies and term neonates with brain injuries due to environmental hypoxia or genetic causes. Anca Pasca, M.D., shares her work to understand the molecular mechanisms underlying neurodevelopmental disorders associated with fetal and neonatal brain injury. Series: "Women in Science" [Health and Medicine] [Science] [Show ID: 39453]…

Stem Cell Channel (Audio)

1
Stem Cells and Science in Space - Medicine Informing Novel Discoveries (MIND) 53:49

50 weeks ago53:49

53:49

Explore cutting-edge research at the intersection of neuroscience, space exploration, and medical innovation. Researchers discuss revolutionary experiments with brain organoids cultivated from stem cells, conducted both in terrestrial labs and aboard the International Space Station. They investigate accelerated aging, neuroprotective agents, and potential treatments for conditions like Alzheimer's and ALS. The dialogue also delves into the transformative impact of space environments on scientific discoveries, from understanding bacterial growth to developing novel therapies. Through collaborative efforts, they strive to revolutionize healthcare, offering hope for patients and pushing the boundaries of human knowledge. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39632]…

Stem Cell Channel (Audio)

1
Stem Cells and Space: Global Astrobiotechnology Hub 54:26

51 weeks ago54:26

54:26

Marking the one-year anniversary of the Global Astrobiotechnology Hub, an esteemed panel convenes to envision the future of space exploration and stem cell research. Central to their discussion is the imperative to enhance accessibility and expedite scientific inquiry in space. They advocate for a shift towards establishing regular access to space, enabling frequent dispatches of payloads and experiments. They highlight the pressing need to advance technology to democratize space research, opening doors for nontraditional researchers from industry, academia, and beyond. They emphasize the significance of scientist-astronauts who possess a nuanced understanding of research methodologies. Emphasizing the importance of public engagement, they underscore the need to disseminate research findings widely and mentor the upcoming generation of scientists. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39528]…

Stem Cell Channel (Audio)

1
Skin Development and Regeneration in Homeostasis and Disease with Elena Ezhkova - Breaking News in Stem Cells 1:05:49

1 year ago1:05:49

1:05:49

Elena Ezhkova, Ph.D., discusses the role of Merkel cells in touch sensation and their connection to nerves. She shares research on skin cancer formation, focusing on the PRC1 complex's impact on gene expression. Ezhkova also investigates epithelial-to-mesenchymal transition (EMT), finding it contributes to cancer spread. Ezhkova offers insights for potential cancer treatments. Series: "Women in Science" [Health and Medicine] [Show ID: 38335]…

Stem Cell Channel (Audio)

1
Modeling Development with Stem Cells with Amander Clark - Breaking News in Stem Cells 1:07:59

1 year ago1:07:59

1:07:59

Amander Clark, Ph.D., delves into crafting artificial ovaries for fertility and aging research. She stresses the importance of diversity in stem cell studies to ensure comprehensive findings. By assembling ovarian models from various genetic backgrounds, her team aims for inclusive representation in biomedical research, potentially offering insights into reproductive health and disease. Series: "Women in Science" [Health and Medicine] [Show ID: 38334]…

Stem Cell Channel (Audio)

1
Dissecting Human HSC Self-Renewal Mechanisms Throughout Ontogeny with Hanna Mikkola - Sanford Stem Cell Symposium 2023 33:15

1 year ago33:15

33:15

Hanna Mikkola, M.D., Ph.D., shares her work in hematopoietic stem cells (HSCs) and their complex renewal process. Her research aims to unravel these cells' behavior in mice and humans, offering potential insights for future medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39258]…

Stem Cell Channel (Audio)

1
Examining the Therapeutic Potential of Stem Cell Derived Microglia with Mathew Blurton-Jones - Breaking News in Stem Cells 1:18:20

1 year ago1:18:20

1:18:20

Mathew Blurton-Jones presents CRISPR-based interventions for a rare brain disorder in mice by substituting defective brain cells with healthy ones. He details experiments demonstrating the efficacy of corrected cells in mitigating brain pathologies. Blurton-Jones emphasizes the need for cautious translation to human trials, advocating gradual cell replacement to preempt potential adverse effects. Additionally, he delves into the implications of microglia in Alzheimer's disease progression and explores potential interconnections among various neurodegenerative conditions. Series: "Stem Cell Channel" [Health and Medicine] [Show ID: 38333]…

Stem Cell Channel (Audio)

1
Prenatal Inflammation Shapes Postnatal Immune Function by Reprogramming Fetal Hematopoiesis with Anna Beaudin - Sanford Stem Cell Symposium 2023 37:24

1 year ago37:24

37:24

Anna Beaudin, Ph.D., delves into the intricacies of how prenatal inflammation impacts the immune system's blueprint, shaping its long-term function. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39257]

Stem Cell Channel (Audio)

1
Working Together for Better Patient Care: Alpha Clinic Directors Panel - Sanford Stem Cell Symposium 2023 56:27

1 year ago56:27

56:27

Stem Cell Channel (Audio)

1
Stem Cells and Space - Sanford Stem Cell Symposium 2023 55:24

1 year ago55:24

55:24

Experts discuss the immense potential of conducting experiments and manufacturing goods in space. They explore how this could enhance our understanding of health issues, unveil new discoveries, and produce innovative technology for use on Earth. The conversation encompasses collaborations between various industries and scientists, aiming to explore the distinct conditions in space to enhance life for all. Featuring: Catriona Jamieson, M.D., Ph.D. UC San Diego Jana Stoudemire, M.Bio. Axiom Space Alain Berinstain, Ph.D. Space Tango Marc Giulianotti, Ph.D. Sierra Space Kevin Engelbert, M.S.F. NASA Michael Roberts, Ph.D. CASIS Arun Sharma, Ph.D. Cedars Sinai Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39072]…

Stem Cell Channel (Audio)

1
Using Stem Cells to Model and Treat Human Disease with Clive Svendsen - Sanford Stem Cell Symposium 2023 40:27

1 year ago40:27

40:27

Clive Svendsen, Ph.D., leads groundbreaking experiments using stem cell transplants, uncovering unexpected findings. These trials aimed at improving ALS treatments, revealed higher success with upper motor neuron transplants compared to spinal cord methods. Svendsen's exploration of cortical transplants hints at a potential breakthrough. Moreover, his study of stem cell behavior in space opens doors to exciting medical advancements. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39068]…

Stem Cell Channel (Audio)

1
Organoids to Model Human Diseases with Hans Clevers - Sanford Stem Cell Symposium 2023 40:39

1 year ago40:39

40:39

Hans Clevers, M.D., Ph.D., shares his research at the intersection of medicine and biology. Clevers discusses revolutionary advances in personalized medicine, where patient-specific treatments can be developed by studying small samples of patients' tissues. He explores the role of specialized cells known as "best for cells" in gastrointestinal health, shedding light on how they may help fight infections. Additionally, he highlights how mini-organs, or organoids, grown in the lab help us understand complex cellular functions and diseases. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39066]…

Stem Cell Channel (Audio)

1
Regulation of Lung Progenitors in Homeostasis and Injury Repair - Carla Kim Sanford Stem Cell Symposium 2023 29:11

1 year ago29:11

29:11

Carla Kim, Ph.D., explains how aging impacts lung cell biology and its potential to reshape our understanding of diseases, including lung cancer. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39254]

Stem Cell Channel (Audio)

1
Clonal Hematopoiesis in Human Aging and Disease with Siddhartha Jaiswal - Sanford Stem Cell Symposium 2023 28:53

1 year ago28:53

28:53

Siddhartha Jaiswal, M.D., Ph.D., discusses clonal hematopoiesis and its impact on aging and diseases. Jaiswal highlights the role of genetic variations, focusing on a specific gene, TET2, and its link to clonal expansion. He explains that certain genetic variations can slow clonal expansion, potentially offering insights into treatments or interventions to mitigate its effects. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39260]…

Stem Cell Channel (Audio)

1
A Life in Space with Peggy Whitson - Sanford Stem Cell Symposium 2023 39:58

1 year ago39:58

39:58

Astronaut Peggy Whitson, Ph.D., and Lisa Carnell, Ph.D., discuss various aspects of space exploration, life in microgravity, and the future of space science and research. They delve into the challenges astronauts face, from taste differences in space to innovative 3D printing solutions. The conversation also highlights the importance of stem cell research, personalized medicine, and drug development in space. Whitson's unique perspective offers insights into the awe-inspiring views of Earth from space and the collective responsibility to protect our planet. This thought-provoking discussion exemplifies the intersection of science, space exploration, and the promise of a future beyond our planet. Series: "Stem Cell Channel" [Science] [Show ID: 39073]…

Stem Cell Channel (Audio)

1
Telomeres in Cancer and Aging with Ronald DePinho - Sanford Stem Cell Symposium 2023 34:12

1 year ago34:12

34:12

Ronald DePinho, M.D., explains how telomerase, typically linked to telomere maintenance, serves as a transcriptional co-activator in the brain. Epigenetic repression of TERT, the gene for telomerase, occurs with aging, contributing to aging hallmarks like cellular senescence and inflammation. DePinho's team developed a compound that reactivates TERT, which, when administered to mice, reverses age-related changes. It restores cognitive function, reduces amyloid plaque, and alleviates inflammation. This suggests that maintaining TERT levels can counteract age-related cognitive decline and neurodegeneration, offering potential for treating neurodegenerative diseases like Alzheimer's. DePinho's work expands our understanding of telomerase's multifaceted role in aging and neurodegeneration, holding promise for interventions against these age-related processes. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39071]…

Stem Cell Channel (Audio)

1
Clonal Expansion of Blood Stem Cells in Aging and Leukemia with Leonard Zon - Sanford Stem Cell Symposium 2023 48:38

1 year ago48:38

48:38

Leonard Zon, M.D., discusses cutting-edge research on the intricate relationship between macrophages, stem cells, and the development of leukemia using the zebrafish model. He delves into the fascinating interactions between these cell types, highlighting the role of a "don't eat me" signal and the influence of the leukemic niche. Through cellular barcoding and single-cell RNA sequencing, he unveils a potential therapeutic target which may offer promising insights into treating leukemia by disrupting the stromal activities that support it. Zon showcases the power of zebrafish models in advancing our understanding of hematopoiesis and cancer, promising new avenues for research and treatment. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 39064]…

Stem Cell Channel (Audio)

1
Translating Cell Therapies to Clinical Realities with Malcolm Moos Jr. - Breaking News in Stem Cells 1:20:14

1 year ago1:20:14

1:20:14

Are you curious about the future of medical treatments and how they might impact your health? Malcolm Moos, Jr., M.D., Ph.D., shares how cellular therapies are revolutionizing medical treatments. Explore how cells hold the potential to provide new hope for individuals facing various health challenges. Delve into the concept of personalized medicine, discover how regulatory agencies are safeguarding patients' well-being, learn the science behind cell behavior and genetics, and how these processes influence innovative medical treatments and so much more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38330]…

Stem Cell Channel (Audio)

1
Understanding Cell Types in the Developing Human Brain and in Glioblastoma with Aparna Bhaduri - Breaking News in Stem Cells 58:21

2 years ago58:21

58:21

Aparna Bhaduri, Ph.D., shares insights into human brain development and its intricate processes. Explore the intriguing reappearance of developmental cell elements in brain cancers like glioblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38329]

Stem Cell Channel (Audio)

1
Induction of Germ Cell Fate from Mammalian Pluripotent Stem Cells with Toshihiro Kobayashi - Breaking News in Stem Cells 57:27

2 years ago57:27

57:27

Toshihiro Kobayashi, Ph.D., presents his research on the mechanisms driving cell fate choices in early mammalian embryos. He also discusses the potential application of these principles in future regenerative medicine. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38328]

Stem Cell Channel (Audio)

1
Stem Cells and Clinical Genomics for Clinical Trials in Dish - Breaking News in Stem Cells 52:04

2 years ago52:04

52:04

Joseph C. Wu, M.D., Ph.D., shares his pioneering research on cardiovascular disease mechanisms using patient-specific stem cells. Learn about accelerated drug discovery, "clinical trials in a dish," and precision medicine's impact on treatment. Explore genomics, stem cells, imaging, and more. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38327]…

Stem Cell Channel (Audio)

1
Spatial Analysis of RNA Distribution During Early Mouse and Human Embryogenesis - Elsy Buitrago-Delgado 54:45

2 years ago54:45

54:45

Elsy Buitrago-Delgado, Ph.D., shares how spatial analysis of RNA distribution during early mouse embryogenesis suggests that the first cell fate choice is made at the 4-cell stage. She also discusses how notch signaling regulates cell fate choices during early human development. Series: "Stem Cell Channel" [Science] [Show ID: 38888]…

Stem Cell Channel (Audio)

1
Genomic Unraveling of Biological and Clinical Heterogeneity in Medulloblastoma - Paul Northcott 1:07:46

2 years ago1:07:46

1:07:46

Paul A. Northcott, Ph.D., St. Jude Children's Research Hospital, shares his work in multi-omic bulk and single-cell approaches to decipher molecular landscapes and developmental origins of medulloblastoma. Series: "Stem Cell Channel" [Health and Medicine] [Science] [Show ID: 38889]

Stem Cell Channel (Audio)

1
Stem Cell Approaches to Understanding Acquired and Genetic Epilepsies with Jenny Hsieh - Breaking News in Stem Cells 48:00

2 years ago48:00