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American Physiological Society द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री American Physiological Society या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal
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New Permeability Assessment of Microvessels-on-a-Chip

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संग्रहीत श्रृंखला ("निष्क्रिय फ़ीड" status)

When? This feed was archived on September 02, 2022 19:28 (1+ y ago). Last successful fetch was on August 02, 2022 20:36 (1+ y ago)

Why? निष्क्रिय फ़ीड status. हमारे सर्वर निरंतर अवधि के लिए एक वैध डिजिटल ऑडियो फ़ाइल फ़ीड पुनर्प्राप्त करने में असमर्थ थे।

What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.

Manage episode 314984622 series 2369234
American Physiological Society द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री American Physiological Society या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal

Permeability is an important measure of the exchange function of microvessels, but until now, there has been a lack of physiologically-relevant in vitro microvessel models that allow an easy assessment of permeability properties of the microvessel wall. In our latest episode, Associate Editor Amanda LeBlanc (University of Louisville) interviews lead author Ping He (Penn State University) and expert Robert Hester (University of Mississippi Medical Center) about the latest research study by Gao et al., published in the AJP-Heart and Circ Call for Papers on Deconstructing Organs: Single-Cell Analyses, Decellularized Organs, Organoids, and Organ-on-a-Chip Models. Dr. He and colleagues developed a novel microvessel-on-a-chip model which allows endothelial cells to grow under continuous flow, simulating the in vivo environment, while also allowing for the assessment barrier function of the microvessel wall. The in vitro microvessel model Gao et al. developed features layers of glycocalyx and endothelium, and as Dr. He points out, endothelial junctions and glycocalyx are key components contributing to microvessel barrier function and acute inflammatory responses observed in in vivo models. Listen as we discuss the future directions of this model in both acute and chronic conditions, disease states and future molecular studies.

Feng Gao, Haoyu Sun, Xiang Li, Pingnian He Leveraging avidin/biotin interaction to quantify permeability of microvessels-on-a-chip Am J Physiol Heart Circ Physiol, published December 13, 2021. DOI: 10.1152/ajpheart.00478.2021

  continue reading

23 एपिसोडस

Artwork
iconसाझा करें
 

संग्रहीत श्रृंखला ("निष्क्रिय फ़ीड" status)

When? This feed was archived on September 02, 2022 19:28 (1+ y ago). Last successful fetch was on August 02, 2022 20:36 (1+ y ago)

Why? निष्क्रिय फ़ीड status. हमारे सर्वर निरंतर अवधि के लिए एक वैध डिजिटल ऑडियो फ़ाइल फ़ीड पुनर्प्राप्त करने में असमर्थ थे।

What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.

Manage episode 314984622 series 2369234
American Physiological Society द्वारा प्रदान की गई सामग्री. एपिसोड, ग्राफिक्स और पॉडकास्ट विवरण सहित सभी पॉडकास्ट सामग्री American Physiological Society या उनके पॉडकास्ट प्लेटफ़ॉर्म पार्टनर द्वारा सीधे अपलोड और प्रदान की जाती है। यदि आपको लगता है कि कोई आपकी अनुमति के बिना आपके कॉपीराइट किए गए कार्य का उपयोग कर रहा है, तो आप यहां बताई गई प्रक्रिया का पालन कर सकते हैं https://hi.player.fm/legal

Permeability is an important measure of the exchange function of microvessels, but until now, there has been a lack of physiologically-relevant in vitro microvessel models that allow an easy assessment of permeability properties of the microvessel wall. In our latest episode, Associate Editor Amanda LeBlanc (University of Louisville) interviews lead author Ping He (Penn State University) and expert Robert Hester (University of Mississippi Medical Center) about the latest research study by Gao et al., published in the AJP-Heart and Circ Call for Papers on Deconstructing Organs: Single-Cell Analyses, Decellularized Organs, Organoids, and Organ-on-a-Chip Models. Dr. He and colleagues developed a novel microvessel-on-a-chip model which allows endothelial cells to grow under continuous flow, simulating the in vivo environment, while also allowing for the assessment barrier function of the microvessel wall. The in vitro microvessel model Gao et al. developed features layers of glycocalyx and endothelium, and as Dr. He points out, endothelial junctions and glycocalyx are key components contributing to microvessel barrier function and acute inflammatory responses observed in in vivo models. Listen as we discuss the future directions of this model in both acute and chronic conditions, disease states and future molecular studies.

Feng Gao, Haoyu Sun, Xiang Li, Pingnian He Leveraging avidin/biotin interaction to quantify permeability of microvessels-on-a-chip Am J Physiol Heart Circ Physiol, published December 13, 2021. DOI: 10.1152/ajpheart.00478.2021

  continue reading

23 एपिसोडस

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